The township is located at the junction of several major interstate and regional transportation routes, most notably the Schuylkill Expressway (I-76) and the Pennsylvania Turnpike (I-276). These routes provide convenient access to Philadelphia and the New Jersey/New York area. A second major interstate route, which can be accessed via the Pennsylvania Turnpike, is the “Blue Route,” (I-476), which provides access to the Philadelphia International Airport, Northern Delaware, and the Baltimore/Washington area via I-95.
Regional transportation routes include U.S. Routes 202 and 422, which provide access to locations throughout southeastern Pennsylvania
Transit service in Upper Merion is provided both on the local and regional level. High speed rail from the Southeastern Pennsylvania Transportation Authority (SEPTA) provides transit service to and from Philadelphia, while seven SEPTA bus routes service the main business areas of the township. A secondary transit system, the Rambler – operated by the Greater Valley Forge Transportation Management Authority (GVFTMA) – provides local service to Upper Merion residents.